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| Pasha (protein) ： ウィキペディア英語版 |
DGCR8
The DGCR8 microprocessor complex subunit ''(DiGeorge syndrome chromosomal'' (''critical'' ) ''region 8)'' is a protein that in humans is encoded by the ''DGCR8'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54487 )〕 In other animals, particularly the common model organisms ''Drosophila melanogaster'' and ''Caenorhabditis elegans'', the protein is known as ''Pasha'' (partner of Drosha). It is a required component of the RNA interference pathway.
== Function ==
DGCR8 is localized to the cell nucleus and is required for microRNA (miRNA) processing. It binds to Drosha, an RNase III enzyme, to form the ''Microprocessor complex'' that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to miRNA fragments by the enzyme Dicer. DGCR8 contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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